The Moto Guzzi V100 Mandello S features a 1042cc, liquid-cooled, transverse V-twin engine producing 115 horsepower and 77.4 lb-ft of torque, coupled with a six-speed, shaft-driven transmission. Key "S" model upgrades include fully adjustable Öhlins Smart EC 2.0 suspension, adaptive aerodynamics with deployable wings, a PFF Rider Assistance Solution (4D radar) system, and a quickshifter. Other specs include a 17-liter fuel tank, a 5-inch TFT display, and a kerb weight of approximately 514 lbs.